PHARMA
SPECIAL : Flow chemistry
Recent developments in the synthesis of pharmaceutical
products R. Porta et al have given a very useful coverage of this contemporary
subject.
Pharma industry still relies on multipurpose batch or
semi-batch reactors for APIs. However, there is increasing interest as
continuous processes allow safer and more efficient operations and become
almost a necessity when hazardous chemicals are involved.
FDA favours products coming from continuous plants due
to consistency of the product. This strategy also allows combination with other
enabling technologies such as microwave irradiation, supported reagents or
catalysts, photochemistry, inductive heating, electrochemistry, new solvent
systems, and 3D printing.
Of course, microreactors can be used and automation is
facilitated.
Literature from 2013 to 2015 has been covered along
with very recent examples not reported in any published review.
Relatively unexplored field of stereoselective
organocatalysis is also covered.
The field of chiral drugs is covered and overall
perspective is given.
(Org. Proc. Res. Dev., 2015, DOI:
10.1021/acs.oprd.5b00325).
No comments:
Post a Comment